Dynamic Small-Animal PET Imaging of Tumor Proliferation with 39-Deoxy-39-18F- Fluorothymidine in a Genetically Engineered Mouse Model of High-Grade Gliomas
نویسندگان
چکیده
1Department of Radiology, Sloan Kettering Institute for Cancer Research, New York, New York; 2Cancer Biology and Genetics, Sloan Kettering Institute for Cancer Research, New York, New York; 3Department of Medical Physics, Sloan Kettering Institute for Cancer Research, New York, New York; 4Cyclotron and Radiochemistry Core, Sloan Kettering Institute for Cancer Research, New York, New York; 5Small-Animal Imaging Core Facility, Sloan Kettering Institute for Cancer Research, New York, New York; and 6Neurosurgery Service, Sloan Kettering Institute for Cancer Research, New York, New York
منابع مشابه
Dynamic small-animal PET imaging of tumor proliferation with 3'-deoxy-3'-18F-fluorothymidine in a genetically engineered mouse model of high-grade gliomas.
UNLABELLED 3'-Deoxy-3'-(18)F-fluorothymidine ((18)F-FLT), a partially metabolized thymidine analog, has been used in preclinical and clinical settings for the diagnostic evaluation and therapeutic monitoring of tumor proliferation status. We investigated the use of (18)F-FLT for detecting and characterizing genetically engineered mouse (GEM) high-grade gliomas and evaluating the pharmacokinetic...
متن کاملDiagnostic Performance and Safety of Positron Emission Tomography Using 18F-Fluciclovine in Patients with Clinically Suspected High- or Low-grade Gliomas: A Multicenter Phase IIb Trial
Objective(s): The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer 18F-fluciclovine (anti-[18F]FACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas.Methods: Anti-[18F]FACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET...
متن کاملImaging Cellular Proliferation in Prostate Cancer with Positron Emission Tomography
Prostate cancer remains a major public health problem worldwide. Imaging plays an important role in the assessment of disease at all its clinical phases, including staging, restaging after definitive therapy, evaluation of therapy response, and prognostication. Positron emission tomography with a number of biologically targeted radiotracers has been demonstrated to have potential diagnostic and...
متن کاملMismatched intratumoral distribution of [18F] fluorodeoxyglucose and 3′-deoxy-3′-[18F] fluorothymidine in patients with lung cancer
In a mouse model of human lung cancer, intratumoral distribution between 3'-deoxy-3'-[18F] fluorothymidine (18F-FLT) and [18F] fluorodeoxyglucose (18F-FDG) was mutually exclusive. 18F-FLT primarily accumulated in proliferating cancer cells, whereas 18F-FDG accumulated in hypoxic cancer cells. The aim of the present study was to evaluate these preclinical findings in patients with lung cancer. A...
متن کاملPreliminary 19F-MRS Study of Tumor Cell Proliferation with 3′-deoxy-3′-fluorothymidine and Its Metabolite (FLT-MP)
The thymidine analogue 3'-deoxy-3'-[18F]fluorothymidine, or [18F]fluorothymidine ([18F]FLT), is used to measure tumor cell proliferation with positron emission tomography (PET) imaging technology in nuclear medicine. FLT is phosphorylated by thymidine kinase 1 (TK1) and then trapped inside cells; it is not incorporated into DNA. Imaging with 18F-radiolabeled FLT is a noninvasive technique to vi...
متن کامل